Multi B’s

Multi B’s

Clinical Applications

  • Supports Cardiovascular and Neurologic Health
  • Supports Homocysteine Balance
  • Supports Healthy Arterial Function
  • Maintains a Healthy Inflammatory Response


This product contains targeted amounts of folic acid, B12, B6 and betaine (trimethylglycine) to aggressively support methylation pathways in the body, specifically targeting homocysteine recycling for optimal cardiovascular and arterial health.


Methylation is a vitamin-requiring biochemical process in the body that is critical for maintaining mental and physical health. Methylation helps convert the problematic amino acid metabolite homocysteine into the amino acids methionine and cysteine. Consistent recycling of homocysteine, is vital for supporting cardiovascular health. Proper methylation can be inhibited by nutrient deficiencies including folic acid, B6 and B12. Certain medications such as acetaminophen, aspirin, ibuprofen and oral contraceptives can also deplete blood levels of these crucial B vitamins, reducing the body”™s vital methylation capacity.


Adequate folate status is critical for maintaining optimal methylation, red blood cell balance, DNA and RNA synthesis, and healthy cell division and replication. Folic acid is converted into its metabolically active form, 5-MTHF by the enzyme methylenetetrahydrofolate reductase (5-MTHFR). [1] 5-MTHF donates its methyl group to vitamin B12 (cobalamin), forming methylcobalamin. Methylcobalamin helps convert the problematic amino acid metabolite homocysteine into the amino acid methionine. [2] Consistent recycling of homocysteine is vital to supporting cardiovascular and arterial health.” 


Vitamin B12, methylcobalamin, works along with folic acid in many body processes, including the synthesis of DNA, red blood cells and supporting health of the myelin sheath, the insulating exterior that surrounds nerve cells.[2] B12 is found primarily in animal foods. Vegetarians and the elderly are at highest risk of B12 deficiency. [2] B12 is considered by many to be the second most important nutrient required to balance homocysteine levels. Methylcobalamin is the biologically active form of B12 and supports up-regulation of methylation pathways. [2]” 


Vitamin B6 (pyridoxine) is a B vitamin that is required for more than 60 different enzymatic reactions that occur in the body. [2] Vitamin B6 works along with folic acid and B12 for in the recycling of homocysteine. B6 also supports a healthy cardiovascular system by promoting healthy platelet aggregation and aids in maintaining healthy blood pressure. [3] Vitamin B6 is required for the activation of lysyl oxidase, an enzyme responsible for the cross-linking of collagen and elastin- a factor which is crucial for maintaining healthy circulation and arterial function. [4]” 

Trimethylglycine (Betaine)

Trimethylglycine (Betaine) functions in the body as a unique methyl donor, supporting liver function and detoxification pathways and the conversion of homocysteine to methionine. [5,6] Trimethylglycine also works alongside B6, B12 and folic acid in maintaining normal homocysteine levels.” 

”  This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Additional information


1. 5-methyltetrahydofolate. Altern Med Review 2006; 11(4).
2. Murray MT. Encyclopedia of Nutritional Supplements.
(1996);Prima Publishing: Rocklin, CA.
3. Ayback M. Effect of oral pyroxidine hydrochloride
supplementation on arterial blood pressure in patients
with essential hypertension. Arzneim Forsh 1995;45:1271-
4. Levene CI, Murray JC. The aetiological role of maternal
B6 deficiency in the development of atherosclerosis.
Lancet 1977;i:628-629.
5. Junnila M, Barak AJ, Beckenhauer HC, Rahko T. Betaine
reduces hepatic lipidosis induced by carbon
tetracholoride in Sprague-Dawley rats. Vet Hum Toxicol
6. Kim SK, Kim YC, Kim YC. Effects of singly administered
betaine on hepatotoxicity of chloroform in mice. Food
Chem Toxicol 1998;36: 655- 61.

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